Methods and compositions for regenerating connective tissue

Details Methods and compositions for regenerating connective tissue Methods and compositions for regenerating connective tissue

A - Human Necessities

61

L

A61L 26/00 (2006.01) A61L 27/26 (2006.01) A61L 27/52 (2006.01)

Patent

CA 2543255

Connective tissue regenerative compositions and methods of repairing and regenerating connective tissue using such compositions are provided. The compositions generally comprise a bioactive hydrogel matrix comprising a polypeptide, such as gelatin, and a long chain carbohydrate, such as dextran. The hydrogel matrix may further include polar amino acids, as well as additional beneficial additives. Advantageously, the compositions include further components, such as osteoinductive or osteocon-ductive materials, medicaments, stem or progenitor cells, and three-dimensional structural frameworks. The compositions are useful for regenerating connective tissue, and can be administered to an area having injury to, or a loss of, connective tissue, such as bone, cartilage, tendon, and ligament.

L'invention concerne des compositions de régénération du tissu conjonctif et des méthodes destinées à réparer et régénérer le tissu conjonctif au moyen de ces compositions. Ces compositions comprennent généralement une matrice d'hydrogel bioactive renfermant un polypeptide, tel qu'une gélatine, et un hydrate de carbone à chaîne longue, tel que le dextrane. La matrice d'hydrogel peut en outre comprendre des acides aminés polaires ainsi que des additifs bénéfiques additionnels. Avantageusement, ces compositions comprennent d'autres ingrédients, tels que des matières ostéoinductrices ou ostéoconductrices, des médicaments, des cellules souches ou progénitrices et des charpentes structurales tridimensionnelles. Lesdites compositions sont utiles pour la régénération du tissu conjonctif et peuvent être administrées dans une région présentant une lésion du tissu conjonctif ou une perte de tissu conjonctif, telle qu'un os, un cartilage, un tendon ou un ligament.

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