Swellable particles for drug delivery

Details Swellable particles for drug delivery Swellable particles for drug delivery

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 31/195 (2006.01)

Patent

CA 2648291

Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 µm or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 µm volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.

L'invention concerne des particules gonflantes pour l'administration d'un médicament ou d'un autre agent actif dans le système pulmonaire. Ces particules gonflantes présentent un diamètre aérodynamique des particules déshydratées (sèches) inférieur ou égal à 5 µm, ce qui permet une administration dans le tractus respiratoire, et notamment dans les voies respiratoires trachéo-bronchiques du tractus respiratoire supérieur et/ou dans les régions alvéolaires du poumon profond, et un diamètre des particules hydratées supérieur au diamètre moyen en volume de 6 µm, ce qui permet de retarder ou prévenir leur phagocytose par les macrophages présents dans les voies respiratoires du tractus respiratoire.

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