Polyol-ifn-beta conjugates

Details Polyol-ifn-beta conjugates Polyol-ifn-beta conjugates

C - Chemistry, Metallurgy

07

K

C07K 14/565 (2006.01) A61K 38/21 (2006.01) A61K 47/48 (2006.01) A61P 37/04 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2330451

PEG-IFN-.beta. conjugates, where a PEG moiety is covalently bound to Cys17 of human IFN-.beta., are produced by a process of site specific PEGylation with a thiol reactive PEGylating agent. A pharmaceutical composition and a method for treating infections, tumors and autoimmune and inflammatory diseases are also provided. The invention further relates to a method for the stepwise attachment of PEG moieties in series to a polypeptide, and more particularly to IFN-.beta..

On prépare des conjugués de PEG-IFN-.beta. dans lesquels une fraction de PEG est liée de façon covalente à Cys?17¿ de IFN-.beta. humain, au moyen d'un procédé de PEGylation régiospécifique avec un agent de PEGylation réactif avec thiol. L'invention concerne également une composition pharmaceutique et un procédé servant à traiter des infections, des tumeurs ou des maladies auto-immunes et inflammatoires. Elle concerne également un procédé de fixation progressive de fractions de PEG en série à un polypeptide et, plus particulièrement, à IFN-.beta..

Affiliated with

Also associated with

Rating

Polyol-ifn-beta conjugates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polyol-ifn-beta conjugates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polyol-ifn-beta conjugates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1520168