Nucleic acids for apoptosis of cancer cells

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/11 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2592562

The disclosure relates to a nucleic acid having an Apoptotic Sequence of: Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, and Seq.ID.No:7. It also relates to a compsoition including a nucleic acid having an Apoptotic Sequence of Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, and Seq.ID.No:7. The composition may also include a pharmaceutically acceptable carrier. The disclosure also includes a method of killing a cancer cell by administering to a cancer cell a serum including a nucleic acid having an Apoptotic Sequence of: Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, and Seq.ID.No:7 and a pharmaceutically acceptable carrier. The cancer cell may be located in a subject with cancer.

L'invention porte sur un acide nucléique possédant une séquence d'apoptose de: Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, et Seq.ID.No:7. Elle concerne aussi une composition contenant un acide nucléique présentant une séquence d'apoptose de Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, et Seq.ID.No:7. Cette composition peut aussi contenir un support pharmaceutiquement acceptable. L'invention se rapporte également à un procédé d'élimination d'une cellule cancéreuse par administration, dans une cellule cancéreuse, d'un sérum contenant un acide nucléique possédant une séquence d'apoptose de: Seq.ID.No:1, Seq.ID.No:2, Seq.ID.No:3, Seq.ID.No:4, Seq.ID.No: 5, Seq.ID.No:6, et Seq.ID.No:7 ainsi qu'un support pharmaceutiquement acceptable. Cette cellule cancéreuse peut se situer dans un sujet atteint d'un cancer.

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