C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7125 (2006.01) A61K 39/39 (2006.01) A61K 45/00 (2006.01) A61P 37/04 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2376634
The invention relates to an oligonucleotide which can stimulate human cells of the immune system, characterized in that it comprises at least one nucleotide sequence of formula 5'TTN1N2TT3' wherein T represents thymine, and N1 and N2 can both represent adenine, thymine, cytosine or guanine. The invention is further characterized in that it is devoid of the CG dinucleotide in which cytosine C is not methylated. One oligonucleotide of particular interest has the following sequence: 5'TTAGTTCTTAGTTN3TTAGTT 3'. Said oligonucleotide can be used in a particularly advantageous manner as an adjuvant for vaccines.
L'invention concerne un oligonucléotide capable de stimuler des cellules humaines du système immunitaire, caractérisé en ce qu'il comprend au moins une séquence nucléotidique ayant la formule suivante 5' T T N¿1? N¿2? T T 3', dans laquelle T signifie Thymine, N¿1? et N¿2? peuvent chacun représenter l'Adénine, la Thymine, la Cytosine ou la Guanine, et en ce qu'il est dépourvu de dinucléotide CG dans lequel la Cytosine C ne serait pas méthylée. En particulier, un oligonucléotide d'intérêt présente la séquence suivante: 5' TTAGTTCTTAGTTN¿3?TTAGTT 3'. Un tel oligonucléotide trouve une application particulièrement intéressante comme adjuvant vaccinal.
Bachy Monique
Sodoyer Regis
Trannoy Emmanuelle
Aventis Pasteur
Robic
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