Pyrazolopyridine compound and processes for preparation thereof

Details Pyrazolopyridine compound and processes for preparation thereof Pyrazolopyridine compound and processes for preparation thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2047283

Pyrazolopyridine compounds of the following formula: Image wherein R1 is aryl, and R2 is amino(lower)alkyl; lower alkylamino- (lower)alkyl; carboxy(lower)- alkylamino(lower)alkyl; protected carboxy(lower)alkylamino- (lower)alkyl; lower alkylamino- (lower)alkyl having hydroxy and aryloxy; protected amino(lower)alkyl; cyano(lower)alkyl; cyano(higher)alkyl; lower alkyl having heterocyclic group, in which heterocyclic group may have one or more suitable substituent(s); higher alkyl having heterocyclic group, in which heterocyclic group may have one or mare suitable substituent(s); ar(lower)alkyl; lower alkenyl; or heterocyclic group which may have one or more suitable substituent(s), and pharmaceutically acceptable salts thereof. Also disclosed is a process of preparing these compounds, pharmaceutical compositions containing them and their use for treating and/or preventing melancholia, heart failure, hypertension, renal failure, renal toxicity. nephrosis, nephritis, edema, obesity, bronchial asthma, gout, hyperuricemia, sudden infant death syndrome, immunosuppression, diabetes, ulcer, pancreatis, myocardiac infarction, thrombosis, obstruction, arteriosclerosis obliterans, thrombo- phlebitis, cerebral infarction, transient ischemic attack or angina pectoris by adminsitration to a human being or an animal.

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