Production of human papillomavirus capsid protein and...

Details Production of human papillomavirus capsid protein and... Production of human papillomavirus capsid protein and...

C - Chemistry, Metallurgy

12

N

C12N 15/37 (2006.01) A61K 39/12 (2006.01) C07K 14/025 (2006.01) C12N 7/04 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2157932

The present invention is directed to a method of expressing the papillomavirus capsid protein coding sequence in a cell using an expression system under conditions facilitating expression of the protein in the cell. In another aspect of the invention, it has been discovered that virus-like particle(s)(VLPs), fragment(s), capsomer(s) or portion(s) thereof are formed from the papillomavirus capsid protein. It was further discovered that the virus-like particle(s) comprises antigenic characteristics similar to those of native infectious papillomavirus particles. In one embodiment of the invention, there is provided a method of expressing the L1 major capsid protein of human papillomavirus type-6 (HPV-6) and type-11 (HPV-11) in Sf-9 insect cells using the baculovirus expression system, and the production of type-6 (HPV-6), typo-11 (HPV-11), type-16 (HPV-16) and type-18 (HPV-18) virus-like particles.

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