C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/745 (2006.01) C07K 1/22 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2332571
A novel peptide having a .beta.1-3-galactose-.beta.1-3-galactose-.beta.1-4- xylose glucuronate chain having been sulfated at the 3-position and exhibiting a thrombomodulin activity; medicinal compositions containing this peptide as the active ingredient; a therapeutic method with the use of the same; a method for separating the above peptide by affinity chromatography with the use of antiHNK-1 antibody; and an enzyme immunoassay method by using the antiHNK antibody.
L'invention concerne un nouveau peptide possédant une chaîne de .beta.1-3-galactose-.beta.1-3-galactose-.beta.1-4-xylose glucuronate, qui a été sulfaté en position 3 et qui manifeste une activité de thrombomoduline. L'invention concerne également des compositions pharmaceutiques comprenant ce peptide en tant que composant actif, un procédé thérapeutique utilisant ces compositions, un procédé pour séparer ce peptide par affinité chromatographique avec l'utilisation d'un anticorps antiHNK-1 et un procédé d'examen immunologique aux enzymes utilisant l'anticorps antiHNK-1.
Hase Sumihiro
Wakabayashi Hiroyuki
Mochida Pharmaceutical Co. Ltd.
Smart & Biggar
LandOfFree
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