C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4439 (2006.01) A61P 1/00 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) C07D 413/14 (2006.01)
Patent
CA 2554894
The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4 X7, X8, R1, R2, R3, m, n, and p are as defined as in formula (I), or salts, or hydrates thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy, especially for the treatment of mGluR5 receptor mediated disorders, and for the treatment of neurological disorders, psychiatric disorders, gastrointestinal disorders and pain disorders.
L'invention porte sur de nouveaux composés de formule (I) dans laquelle: P, Q, X?1¿, X?2¿, X?3¿, X?4¿ X?7¿, X?8¿, R?1¿, R?2¿, R?3¿, m, n, et p sont tels que définis dans la description, et sur leurs sels et hydrates. L'invention porte également sur leurs procédés de préparation, sur de nouveaux intermédiaires utilisés dans leur préparation, sur des préparations pharmaceutiques les contenant, et sur leur utilisation en thérapie, spécialement pour le traitement de troubles neurologiques, psychiatriques, gastro-intestinaux, et celui de la douleur.
Edwards Louise
Isaac Methvin
Johansson Martin
Malmberg Johan
Minidis Alexander
Astrazeneca Ab
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Nps Pharmaceuticals Inc.
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