Treatment of solid cancers

A - Human Necessities – 61 – K

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Details

A61K 36/47 (2006.01) A61K 31/22 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2589992

The present invention relates generally to the field of cancer including tumor therapy. More particularly, the present invention relates to the treatment of solid cancers, including solid tumors, and the prevention or reduction of cancer metastasis, by chemoablation of cancer cells by an agent which also stimulates the generation of cancer-specific T-cells, a process referred to herein as immunostimulatory chemoablation. The present invention further contemplates combination therapy comprising immunostimulatory chemoablation and one or more other therapeutic regimens, which enhance, co-operate and/or synergize with the cancer-specific T-cells induced by the chemoablation. The present invention also relates to pharmaceutical compositions for use in treating cancers.

La présente invention a pour objet général le domaine du cancer, y compris des thérapies visant des tumeurs. La présente invention a plus particulièrement pour objet le traitement de cancers solides, y compris de tumeurs solides, ainsi que la prévention ou la réduction de métastases cancéreuses, par ablation chimique de cellules cancéreuses à l'aide d'un agent qui stimule également la génération de cellules T spécifiques de cancers. Ce procédé est appelé dans la suite ablation chimique immunostimulante. La présente invention concerne en outre une thérapie combinatoire qui fait intervenir l'ablation chimique immunostimulante, ainsi qu'un ou plusieurs régimes thérapeutiques, lesdits régimes amplifiant l'action, coopérant et/ou entrant en synergie avec les cellules T spécifiques d'un cancer induites par l'ablation chimique. La présente invention concerne également des préparations pharmaceutiques pouvant être employées dans le traitement des cancers.

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