Use of cgrp antagonists in treatment and prevention of hot...

A - Human Necessities – 61 – K

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A61K 31/551 (2006.01) A61P 5/24 (2006.01) A61P 15/00 (2006.01)

Patent

CA 2592278

The invention relates to a method of treatment or prevention of hot flushes in men who underwent castration, e.g. due to androgen ablation treatment in prostate cancer therapy, comprising administration of an effective amount of a selected CGRP antagonist to the patient, and to the use of said active compounds for the manufacture of a pharmaceutical composition intended to be used in this method.

L'invention concerne un procédé pour traiter ou prévenir les bouffées de chaleur chez des hommes ayant subi une castration, par exemple à cause d'un traitement supprimant la production des androgènes en thérapie du cancer de la prostate, comprenant l'administration au patient d'une quantité efficace d'un antagoniste du CGRP choisi et l'utilisation desdits composés actifs pour la fabrication d'une composition pharmaceutique destinée à être utilisée dans ce procédé.

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