Use of an adenosine antagonist

Details Use of an adenosine antagonist Use of an adenosine antagonist

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61K 31/4375 (2006.01) A61K 31/4418 (2006.01) A61K 31/519 (2006.01) A61K 31/522 (2006.01) A61K 31/7076 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2669166

Uses for a selective adenosine A3 receptor antagonist, or RNAi directed against said receptor, to treat myocardial infarction and heart conditions including heart failure, are provided. Optionally, an adenosine A2a receptor agonist may also be used with the adenosine A3 receptor antagonist. Methods of treating heart failure are also provided.

La présente invention concerne des utilisations d'un antagoniste sélectif du récepteur A3 de l'adénosine, ou d'ARNi dirigés contre ce récepteur, pour traiter l'infarctus du myocarde et des pathologies cardiaques telles que l'insuffisance cardiaque. Un agoniste du récepteur A2a de l'adénosine peut éventuellement aussi être utilisé conjointement à l'antagoniste du récepteur A3 de l'adénosine. Cette invention concerne également des méthodes de traitement de l'insuffisance cardiaque.

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