C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 209/68 (2006.01) C07C 309/65 (2006.01) C07C 309/72 (2006.01)
Patent
CA 2592450
A new process for preparation of 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl- 3-phenylpropylamine from 3,4-dihydro-6-methyl-4-phenyl-2-benzopyran-2-one is characterized by intermediates such as 3-(2-hydroxy-5-methyl phenyl)-3- phenylpropanol and its sulphonated derivatives and amination in presence of sodium iodide.
L'invention concerne un nouveau procédé de préparation de 3-(2-hydroxy-5-méthylphényl)-N,N-diisopropyl-3-phénylpropylamine à partir de 3,4-dihydro-6-méthyl-4-phényl-2-benzopyran-2-one caractérisé par des intermédiaires tels que 3-(2-hydroxy-5-méthyl phényl)-3-phénylpropanol et ses dérivés sulfonés ainsi qu'une amination en présence d'iodure de sodium.
Goudreau Gage Dubuc
Lek Pharmaceuticals D.d.
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