C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2274739
The present invention provides a human apoptosis-related calcium-binding protein (HARC) and polynucleotides which identify and encode HARC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HARC and a method for producing HARC. The invention also provides for agonists, antibodies, or antagonists specifically binding HARC, and their use, in the prevention and treatment of diseases associated with expression of HARC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HARC for the treatment of diseases associated with the expression of HARC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HARC.
L'invention a trait à une protéine humaine liant le calcium lors de l'apoptose (HARC) et aux polynucléotides identifiant et codant la protéine HARC. Elle porte aussi sur les vecteurs d'expression génétique et les cellules hôte comprenant les séquences nucléotidiques codant la protéine HARC et une méthode de production d'HARC. L'invention se rapporte aux agonistes, anticorps et antagonistes liant la protéine HARC, et leur utilisation, dans la prévention et le traitement des maladies associées à l'expression de la protéine HARC. Par ailleurs, l'invention porte sur l'utilisation de molécules antisens aux polynucléotides codant la protéine HARC pour le traitement des maladies associées à l'expression d'HARC. Les méthodes diagnostiques, qui utilisent le polynucléotide, ou fragments ou complément, et les anticorps spécifiquement liés à la protéine HARC, font aussi l'objet de cette invention.
Goli Surya K.
Hillman Jennifer L.
Incyte Genomics Inc.
Incyte Pharmaceuticals Inc.
Smart & Biggar
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