C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) C07K 14/29 (2006.01) C07K 16/12 (2006.01) C12N 15/74 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2256532
Disclosed is an isolated gene encoding a 120 kDa immunodominant antigen of Ehrlichia chaffeensis. The 120 kDa protein is one of the immunodominant proteins of E. chaffeensis that stimulates production of specific antibodies in infected humans. Also disclosed are the amino acid sequence of the 120 kDa antigen. Methods of producing a recombinant 120 kDa antigen and therapeutic methods of use of the antigen are also disclosed.
L'invention concerne un gène isolé codant un antigène immunodominant de 120 kDa de Ehrlichia chaffeensis. La protéine de 120 kDa est l'une des protéines immnuodominantes de E. chaffeensis stimulant la production d'anticorps spécifiques chez les êtred humains infectés. On décrit par ailleurs la séquence d'acides aminés dudit antigène de 120 kDa ainsi que les procédés de génie génétique pour l'élaboration d'un antigène de 120 kDa et les moyens d'utilisation thérapeutique correspondants.
Walker David H.
Yu Xue-Jie
Board Of Regents The University Of Texas System
Borden Ladner Gervais Llp
Research Development Foundation
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