Methods and compositions for treating esophageal disorders

Details Methods and compositions for treating esophageal disorders Methods and compositions for treating esophageal disorders

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/195 (2006.01) A61K 31/27 (2006.01) A61K 31/341 (2006.01) A61K 31/4164 (2006.01) A61K 31/4184 (2006.01) A61K 31/426 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/575 (2006.01) A61K 31/785 (2006.01) A61K 33/08 (2006.01) A61K 33/10 (2006.01) A61K 45/06 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2673665

Disclosed herein are novel compositions for treating or preventing upper GI tract disorders and protecting stratified squamous epithelium against injury by a noxious substance. The pharmaceutical composition comprises at least one bile acid sequestrant, alone or in combination with at least one proton pump inhibitor, and optionally one or more agent chosen from antacids, histamine H2-receptor antagonists, -aminobutyricacid-b (GABA-B) agonists,, prodrugs of GABA-B agonists, and protease inhibitors.

L'invention concerne de nouvelles compositions et méthodes pour le traitement ou la prévention de troubles du tractus gastro-intestinal supérieur et pour la protection de l'épithélium squameux stratifié contre une lésion susceptible d'être causée par une substance toxique. Lesdites méthodes consistent généralement à administrer, à un patient le nécessitant, une dose thérapeutiquement efficace d'une composition pharmaceutique comprenant au moins un séquestrant de l'acide biliaire, seul ou en combinaison avec au moins un inhibiteur de la pompe à protons, et éventuellement un ou plusieurs agents choisis parmi des antiacides, des antagonistes du récepteur H2 de l'histamine, des agonistes de l'acide .gamma.-aminobutyrique B (GABA-B), des promédicaments d'agonistes de GABA-B et des inhibiteurs de protéase.

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