Oligonucleotides for modulating target rna activity

Details Oligonucleotides for modulating target rna activity Oligonucleotides for modulating target rna activity

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01)

Patent

CA 2681568

The present invention describes oligonucleotides that bind to microRNA target sites in target RNAs, such as mRNAs. The oligonucleotides of the invention may mediate RNase H degradation of the target RNA, mediate RNAi of the target RNA or prevent microRNA regulation of the target RNA. The oligonucleotides of the invention are useful e.g. as research tools for studying microRNA:mRNA interactions and for therapeutic development. The present invention also describes methods of identifying microRNA target sites, methods of validating microRNA target sites, methods of identifying oligonucleotides of the invention and methods of modulating the activity of a target RNA using the oligonucleotides of the invention.

La présente invention concerne des oligonucléotides qui se lient à des sites cibles de microARN dans des ARN cibles, tels que des ARNm. Les oligonucléotides de l'invention peuvent assurer la médiation de la dégradation de la RNase H de l'ARN cible, assurer la médiation de l'ARNi de l'ARN cible ou empêcher la régulation du microARN de l'ARN cible. Les oligonucléotides de l'invention sont utiles, par exemple, comme outils de recherche pour l'étude des interactions microARN : ARNm et pour un développement thérapeutique. La présente invention concerne également des procédés d'identification de sites cibles de microARN, des procédés de validation de sites cibles de microARN, des procédés d'identification d'oligonucléotides de l'invention et des procédés de modulation de l'activité d'un ARN cible à l'aide des oligonucléotides de l'invention.

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