Alcohol based topical anesthetic formulation and method

Details Alcohol based topical anesthetic formulation and method Alcohol based topical anesthetic formulation and method

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61K 45/06 (2006.01) A61K 45/08 (2006.01) A61K 47/10 (2006.01) A61K 47/06 (2006.01) A61K 47/26 (2006.01) A61K 47/32 (2006.01)

Patent

CA 2386720

A method for applying a topical anesthetic to an area of skin comprising the steps of a) incorporating an anesthetic in a lipophilic base into a volatile solvent, to form a homogeneous solution; b) applying the homogeneous solution into the area of skin to be treated; and c) evaporating the volatile solvent from the homogeneous solution; wherein the volatile solvent is present in the formulation in amounts between 40 - 80%; and wherein said topical anesthetic rapidly penetrates the skin surface at said skin, leaving a cooling sensation on the skin. The topical anesthetic formulation contains a penetrating enhancer carrier that markedly enhances the delivery of the anesthetic across human skin without altering the acceptable delivery rate of the anesthetic that needs to be delivered through the skin and leaves a cooling sensation on the skin.

Un mode d'application d'un anesthésique topique à une région de la peau comprenant les étapes suivantes : a) incorporer un anesthésique contenu dans une substance lipophile dans un solvant volatile pour créer une solution homogène; b) appliquer la solution homogène sur la région de la peau affectée; c) laisser évaporer le solvant volatile de la solution homogène dans laquelle le solvant représente 40 - 80 % de la formulation et, par ce fait, l'anesthésique topique pénètre rapidement dans la surface de la peau affectée, laissant une sensation de fraîcheur sur la peau. La formulation de l'anesthésique topique contient une composante qui favorise de façon remarquable la pénétration du produit dans la peau sans altérer le taux d'absorption acceptable de l'anesthésique par la peau et y laisse une sensation de fraîcheur.

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