Targeted gene modification by parvoviral vectors

Details Targeted gene modification by parvoviral vectors Targeted gene modification by parvoviral vectors

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/864 (2006.01)

Patent

CA 2289277

This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviruses, including adeno-associated virus (AAV). The parvoviral vectors used in the claimed methods are capable of targeting a specific genetic modification to a preselected target locus in a cellular genome by homologous pairing.

L'invention concerne des procédés permettant d'obtenir une modification génétique ciblée dans des cellules de vertébrés en utilisant des parvovirus, dont des virus adéno-associés (AAV). Les vecteurs parvoviraux utilisés dans les procédés selon l'invention sont capables de provoquer une modification génétique spécifique sur un locus cible présélectionné d'un génome cellulaire par appariement des chromosomes homologues.

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