C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 489/08 (2006.01) A61K 31/485 (2006.01) A61K 47/48 (2006.01) A61P 25/04 (2006.01) A61P 25/36 (2006.01) C07K 5/06 (2006.01) C07K 5/08 (2006.01) C07K 7/06 (2006.01)
Patent
CA 2649360
The invention relates to pharmaceutical compounds and compositions comprised of a chemical moiety attached to oxycodone in a manner that substantially decreases the potential for overdose. When delivered at the proper dosage the pharmaceutical composition provides therapeutic activity similar to that of oxycodone and may also provide sustained release characteristics and/or reduced side-effects. Further the compounds and compositions of the invention are useful in preventing addiction and susceptibility to addiction of oxycodone.
La présente invention concerne des composés et des compositions pharmaceutiques comprenant un fragment chimique lié à une oxycodone d'une manière qui diminue sensiblement le potentiel d'overdose. Lorsqu'elle est administrée à un dosage approprié, la composition pharmaceutique donne une activité thérapeutique analogue à celle de l'oxycodone et peut également donner des caractéristiques d'administration prolongée et/ou une réduction des effets secondaires. En outre, les composés et les compositions de l'invention sont utiles pour prévenir la toxicomanie et plus précisément la toxicomanie à l'oxycodone.
Bera Sanjib
Krishnan Suma
Lauderback Christopher
Mickle Travis
Moncrief James Scott
Gowling Lafleur Henderson Llp
Shire Llc
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