Method for detecting cancer cells and monitoring cancer therapy

Details Method for detecting cancer cells and monitoring cancer therapy Method for detecting cancer cells and monitoring cancer therapy

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 48/00 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2535770

Disclosed herein are methods for identifying cancer cells and monitoring anticancer therapy in the body of a mammal by systemically delivering Sindbis viral vectors. The vector can specifically target and identify tumor cells in mice growing subcutaneously, intraperitoneally, intrapancreatically, or in the lungs. These findings demonstrate the remarkable specificity of the Sindbis vector system that is relatively safe and can specifically target tumor cells throughout the body via the bloodstream.

L'invention concerne des méthodes d'identification de cellules cancéreuses et de surveillance d'une thérapie anticancéreuse dans le corps d'un mammifère par distribution systémique de vecteurs du virus Sindbis. Le vecteur peut spécifiquement cibler et identifier chez des souris des cellules tumorales se développant de manière sous-cutanée, intrapéritonéale, intrapancréatique, ou dans les poumons. Ces découvertes démontrent la remarquable spécificité du système vectoriel du virus Sindbis, qui est relativement sûr et permet de cibler de manière spécifique des cellules tumorales cibles dans tout le corps via le flux sanguin.

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