3-(indol-1-yl)-4-(indol-3-yl)-pyrrole-2,5-diones,3-(benzimid...

Details 3-(indol-1-yl)-4-(indol-3-yl)-pyrrole-2,5-diones,3-(benzimid... 3-(indol-1-yl)-4-(indol-3-yl)-pyrrole-2,5-diones,3-(benzimid...

C - Chemistry, Metallurgy

07

D

C07D 403/14 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 403/04 (2006.01) C07D 477/00 (2006.01) C07D 487/04 (2006.01) C07D 487/22 (2006.01)

Patent

CA 2534528

This invention features compounds of formula (I), (II) and (III), which are useful in the treatment of proliferative disorders characterized by loss of growth or cellular differentiation control including, but not limited to, cancer and inflammation. Formulas (I), (II), (III) have functional groups designated as A1, A2, B1, B2, X1-X9 and Rl -R8 as defined further.

L'invention concerne des composés représentés par la formule (I), (II) et (III), lesquels sont utiles dans le traitement de troubles prolifératifs caractérisés par une perte de croissance ou une régulation de différentiation cellulaire, entre autres, un cancer et une inflammation. Les formules (I), (II) et (III) comportent des groupes fonctionnels représentés par A<1>, A<2>, B<1>, B<2>, X<1>-X<9> et R<l >-R<8> tels que définis plus loin.

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