2-cyclohexyl benzimidazole nmda/nr2b antagonists

Details 2-cyclohexyl benzimidazole nmda/nr2b antagonists 2-cyclohexyl benzimidazole nmda/nr2b antagonists

C - Chemistry, Metallurgy

07

D

C07D 249/16 (2006.01) A61K 31/415 (2006.01) C07D 235/08 (2006.01) C07D 235/10 (2006.01) C07D 235/12 (2006.01) C07D 235/14 (2006.01) C07D 235/16 (2006.01) C07D 235/30 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2389234

Novel 4-substituted cyclohexanes substituted in the 1-position with 2- benzimidazoles, 2-imidazopyridines, or 4-imidazoles either directly or through a C1-C4alkyl, cycloalkyl, hydroxyalkyl, alkoxy or aminoalkyl chain are effective as NMDA NR2B antagonists useful for relieving pain.

L'invention concerne de nouveaux cyclohexanes 4-substitués qui sont substitués en position 1 par des 2-benzimidazoles, des 2-imidazopyridines ou des 4-imidazoles, soit directement, soit à l'aide d'un alkyle C¿1?-C¿4?, d'un cycloalkyle, d'un hydroxyalkyle, d'un alcoxy ou d'une chaîne aminoalkyle. Ces nouveaux cyclohexanes sont efficaces en tant qu'antagonistes NMDA NR2B utiles pour atténuer la douleur.

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