Novel stable crystals of substituted phenylpropionic acid...

Details Novel stable crystals of substituted phenylpropionic acid... Novel stable crystals of substituted phenylpropionic acid...

C - Chemistry, Metallurgy

07

C

C07C 235/60 (2006.01) A61K 31/195 (2006.01) A61P 3/06 (2006.01) C07C 231/24 (2006.01)

Patent

CA 2469882

Preparation of (S)-2-[[3-[N-[4-[(4-fluorophenoxy)phenyl] methyl]carbamoyl]-4-methoxyphenyl]methyl]butanoic acid (referred to as compound (I)) on an industrial scale lies in the finding of homogeneous crystals with excellent stability and the establishment of a preparative process thereof. Novel crystals of compound (I) homogeneous and excellent in the stability characterized by exhibiting the diffraction angles (2.theta.) at least 17.7°, 19.0° and 24.1° in the X-ray powder diffraction are provided by recrystallizing from an alcoholic solvent.

L'invention concerne la production de cristaux homogènes très stables d'acide (S)-2-[[3-[N-[4[(4-fluorophénoxy)phényl]méthyl]carbamoyl]-4-méthoxyphényl]méthyl]butanoïque (composé (I)) sur une échelle industrielle. Les cristaux homogènes du composé (I) de stabilité très élevée sont caractérisés par un diagramme de poudre de diffraction des rayons X présentant des angles de diffraction (2 theta ) de 17,7 DEG , 19,0 DEG et 24,1 DEG après recristallisation dans un solvant alcoolique et purification par traitement au moyen d'un acide ou d'une base.

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