C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 9/10 (2006.01) C12N 15/52 (2006.01) C12N 15/53 (2006.01) C12N 15/76 (2006.01) C12P 19/62 (2006.01)
Patent
CA 2177269
The present invention relates to novel DNA sequences that encode for the branched-chain alpha-ketoacid dehydrogenase complex of an organism belonging to the genus Streptomyces and to novel polypeptides produced by the expression of such sequences. It also relates to novel methods of enhancing the production of natural avermectin, of producing a Streptomyces avermitilis bkd mutant and of producing novel avermectins through fermentation.
La présente invention concerne de nouvelles séquences d'ADN codant pour le complexe alpha-cétoacide ramifié déshydrogénase d'un organisme appartenant aux genre Streptomyces, ainsi que de nouveaux polypeptides produits par l'expression de ces séquences. Elle concerne également de nouvelles méthodes pour améliorer la production d'avermectine naturelle, produire un mutant de Streptomyces avermitilis bkd et produire de nouvelles avermectines par fermentation.
Denoya Claudio Daniel
Stutzman-Engwall Kim Jonelle
Limited Pfizer
Smart & Biggar
LandOfFree
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