Streptomyces avermitilis regulatory genes for increased...

Details Streptomyces avermitilis regulatory genes for increased... Streptomyces avermitilis regulatory genes for increased...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/36 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/01 (2006.01) C12N 15/63 (2006.01) C12N 15/76 (2006.01) C12P 19/62 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2281935

The present invention is directed to compositions and methods for producing avermectins, and is primarily in the field of animal health. The present invention relates to the identification and characterization of two novel genes, herein referred to as the aveR1 and aveR2 genes, that are involved in regulating avermectin polyketide synthase (PKS) expression and avermectin biosynthesis in Streptomyces avermitilis. The present invention is based on the discovery that inactivation of these genes results in an increase in the amount of avermectin produced by S. avermitilis.

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