Recombinant inactivated viral vector vaccine

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/145 (2006.01)

Patent

CA 2744348

A vaccine is described, comprising an inactivated viral vector having inserted an exogenous nucleotide sequence coding for a disease of concern; and, a pharmaceutically acceptable vehicle, adjuvant or excipient, which provides due protection against the disease of concern by using a viral vector titer similar to that required for an active-virus vaccine based on the same viral vector. Mainly, viral vectors of paramixovirus or adenovirus are described.

L'invention concerne un vaccin comprenant un vecteur viral inactivé, dans lequel est insérée une séquence de nucléotides exogène codant pour une maladie d'intérêt, ainsi qu'un véhicule, un adjuvant ou un excipient pharmaceutiquement acceptable, ledit vaccin offrant la protection souhaitée contre la maladie d'intérêt du fait de l'utilisation d'un titre du vecteur viral similaire à celui requis pour un vaccin à virus actif à base du même vecteur viral. L'invention concerne principalement des vecteurs viraux de paramixovirus ou d'adénovirus.

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