Substituted (quinolin-2-yl-methoxy)phenyl-carbonylureas

Details Substituted (quinolin-2-yl-methoxy)phenyl-carbonylureas Substituted (quinolin-2-yl-methoxy)phenyl-carbonylureas

C - Chemistry, Metallurgy

07

D

167/226, 260/288

C07D 215/14 (2006.01) A61K 31/47 (2006.01) C07D 215/16 (2006.01)

Patent

CA 2028314

ABSTRACT OF THE DISCLOSURE Substituted (quinolin-2-yl-methoxy)phenyl- carbonylurea of the formula Image (I) in which A, B, D, E, G, K and M - represent hydrogen, hydroxyl, halogen, carboxyl, nitro, trifluoromethyl, trifluoromethoxy or alkyl or alkoxy, or - represent aryl, which is optionally substituted by halogen, hydroxyl, nitro or cyano, R1 and R2- represent hydrogen or alkyl, which is optionally substituted by halogen, aryl or by cycloalkyl, or - represent cycloalkyl, or - represent aryl, which is optionally substituted by halogen, nitro, cyano or trifluoromethyl, and R3 - represents aryl, which is optionally substituted by halogen, nitro, cyano, trifluoromethyl or alkyl, or - represents alkyl, which is optionally substituted by cycloalkyl, phenyl, carboxyl, halogen, hydroxyl or by alkoxy or alkoxycarbonyl, or - represents cycloalkyl, and their salts are useful for the inhibition of enzymatic reactions in the context of arachidonic acid metabolism. Le A 27 262

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