Modified pf4 compositions and methods of use

Details Modified pf4 compositions and methods of use Modified pf4 compositions and methods of use

C - Chemistry, Metallurgy

07

K

C07K 14/515 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) C07K 7/08 (2006.01) C07K 14/52 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2113206

2113206 9302192 PCTABS00019 The subject invention pertains to the use of modified PF4 and recombinant PF4 (rPF4) as well as modified analogs (mutants) of PF4, and peptide fragments thereof, to inhibit angiogenesis. The modified PF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation. Also, the subject invention concerns modifications of PF4 which extend the half-life and facilitate the targeting of the biological activity of PF4 to specific locations.

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