C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/404 (2006.01) A61P 9/00 (2006.01) C07D 405/04 (2006.01)
Patent
CA 2711815
The invention provides compounds represented by the formula I, each of which compounds may have sphingosine-1 -phosphate receptor agonist and or antagonist biological activity : Formula (I) and wherein the variables Y, R4, n, o, A, A1, A2, X, Z, R1, R3, R2, p, q and r are as defined in the specification. These compounds are useful for treating a disease or condition selected from the group consisting of glaucoma, dry eye, angiogenesis, cardiovascular conditions and diseases, and wound healing.
L'invention porte sur des composés représentés par la formule I, chacun de ces composés pouvant avoir une activité biologique agoniste et/ou antagoniste des récepteurs de la sphingosine-1-phosphate : (I) formule dans laquelle les variables Y, R4, n, o, A, A1, A2, X, Z, R1, R3, R2, p, q et r sont telles que définies dans la description. Ces composés s'utilisent dans le traitement d'une maladie ou d'une affection choisie dans le groupe constitué par le glaucome, l'il sec, l'angiogenèse, les affections et maladies cardiovasculaires et la cicatrisation de plaies.
Beard Richard L.
Donello John E.
Duong Tien T.
Liu Xiaoxia
Yuan Haiqing
Allergan Inc.
Gowling Lafleur Henderson Llp
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