Altered fibronectin-binding protein of staphylococcus aureus

Details Altered fibronectin-binding protein of staphylococcus aureus Altered fibronectin-binding protein of staphylococcus aureus

C - Chemistry, Metallurgy

07

K

C07K 14/31 (2006.01)

Patent

CA 2562037

An isolated, altered fibronectin-binding protein (Fnb) of S. aureus having at least one mutation in an amino acid selected'from residues corresponding to GIn103, GIn105, Lys157, Lys503, Lys620, Lys702, Lys762, Gln783 and Gln830 of FnbA of S. aureus strain ATCC49525 is described. Replacement of these reactive residues within the fibronectin-binding protein renders this protein less capable than wild-type Fnb of covalently cross-linking with fibronectin and fibrin. The altered fibronectin~binding protein effectively interferes with adhesion of S. aureus to fibronectin and fibrin, and therefore, an immunogenic composition comprising such altered Fnb exhibits improved immunogenic properties and is safer to use.

L'invention concerne une protéine de liaison de fibronectine modifiée (Fnb) de S. aureus ayant au moins une mutation dans un acide aminé issu de résidus qui correspondent à GIn103, GIn105, Lys157, Lys503, Lys620, Lys702, Lys762, Gln783 and Gln830 de FnbA de souche de S. aureus ATCC49525. Le remplacement de ces résidus réactifs dans la protéine de liaison de fibronectine rend celle-ci moins capable que la Fnb de type sauvage de réticulation covalente avec la fibronectine et la fibrine. La protéine de liaison de fibronectine modifiée interfère de manière efficace avec l'adhésion de S. aureus à la fibronectine et la fibrine, et il donc plus sûr d'utiliser une composition immunogène qui renferme cette Fnb modifiée car elle a des propriétés immunogènes améliorées.

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