Neurokinine (tachykinine) antagonists

Details Neurokinine (tachykinine) antagonists Neurokinine (tachykinine) antagonists

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 38/05 (2006.01) C07K 5/078 (2006.01) C07K 5/097 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2189764

The invention concerns new amino acid derivatives of general formula (I): R1- R11-A1-B, and pharmaceutically acceptable salts thereof, wherein the group B represents -A2- NR2R3 or R5, R1, A1, A2, R2, R3, R5 and R11 having the meanings indicated in the description. The invention also concerns the production and use of these compounds. The new compounds are valuable neurokinine (tachykinine) antagonists.

L'invention concerne de nouveaux dérivés aminoacides de la formule générale (I): R?1¿-R?11¿-A?1¿-B, et leurs sels pharmaceutiquement acceptables, formule dans laquelle le groupe B représente -A?2¿-NR?2¿R?3¿ ou bien R?5¿, R?1¿, A?1¿, A?2¿, R?2¿, R?3¿, R?5¿ et R?11¿ ayant les notations indiquées dans la description. L'invention concerne également la production et l'utilisation de ces nouveaux composés qui sont de précieux antagonistes de la neurokinine (tachykinine).

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