Process for phenylacetic acid derivatives

Details Process for phenylacetic acid derivatives Process for phenylacetic acid derivatives

C - Chemistry, Metallurgy

07

C

C07C 229/42 (2006.01) C07C 211/52 (2006.01) C07C 211/56 (2006.01) C07C 227/22 (2006.01) C07C 233/15 (2006.01) C07C 235/16 (2006.01) C07C 235/24 (2006.01) C07D 209/34 (2006.01)

Patent

CA 2379553

A process for the production of a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula (II) wherein the symbols are as defined, with a base: and precursors therefor and processes for the preparation of the precursors. The compounds of formula (I) are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase (II).

L'invention concerne un procédé de production d'un composé représenté par la formule générale (I), ou un de ses sels pharmaceutiquement acceptable, ou un de ses prodrogues pharmaceutiquement acceptable. Ce procédé consiste à couper un lactame de la formule générale (II), dans laquelle les symboles sont ainsi définis, avec une base. Cette invention concerne également des précurseurs de ce composé et des procédés servant à la préparation de ces précurseurs. Les composés de la formule générale (I) sont des composés pharmaceutiquement actifs et des inhibiteurs sélectifs de cyclo-oxygénase (II).

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