C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A61K 39/00 (2006.01) A61K 39/02 (2006.01) A61K 39/085 (2006.01) A61K 39/38 (2006.01) C07K 2/00 (2006.01)
Patent
CA 2522400
The Efb protein from Staphylococcus aureus has now been shown to have the ability to bind to the C3 protein which is a crucial component in the activation of complement, and a specific C3 binding region has been located at the C-terminal end of the Efb protein. Isolated proteins and protein fragments containing the Efb protein C3 binding region are thus provided which have complement inhibiting activity, and these proteins and fragments are particularly useful in therapeutic methods wherein the inhibition of complement is desirable, such as in the treatment of hemolytic anemia, the prevention of graft or implant rejection, and to alleviate complement activation that is associated with kidney dialysis methods such as hemodialysis.
On a démontré que la protéine Efb issue de <i>Staphylococcus aureus </i> est capable de se lier à la protéine C3, composant essentiel de l'activation du complément, et une région de liaison à C3 spécifique a été située au niveau de l'extrémité C-terminal de la protéine Efb. L'invention concerne, par conséquent, des protéines isolées et des fragments des protéines renfermant la région de liaison à C3 de la protéine Efb possédant l'activité d'inhibition du complément et particulièrement utiles dans des méthodes thérapeutiques visant à inhiber le complément, telles que celles utilisées dans le traitement de l'anémie hémolytique, la prévention du rejet d'une greffe ou d'un implant, et aux fins d'atténuation de l'activation du complément associée à des méthodes de dialyse des reins, telles que l'hémodialyse.
Brown Eric
Hook Magnus
Lee Lawrence
Blake Cassels & Graydon Llp
The Texas A. & M. University System
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