C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2237739
Currently, there is no method to identify with high specificity and sensitivity, the prion proteins (PrP sc) that lead to the development of the human diseases, Cruetzfeldt-Jakob Disease (CJD) and new variant CJD (nvCJD), also known as bovine spongiform encephalopathy (BSE). The invention is such a diagnostic assay and hereforth defined as PrP-Immuno- PCR. The method involves the combination of two well-described techniques to detect as little as one infectious unit from whole blood using monoclonal antibodies specific to the disease-causing prion proteins and the polymerase chain reaction to amplify such signal using a novel antibody- DNA complex. The method also differentiates the infectious prion PrP sc from a non-infectious cellular prion protein (PrP c) which is found in all healthy individuals.
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