A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/00 (2006.01) C07H 19/00 (2006.01) C12N 11/14 (2006.01)
Patent
CA 2556054
The present invention provides a photoreactive reagent that binds specifically to Ca2+-binding proteins, links to them covalently after photo-activation, and labels them. The novel reagent enables the characterization, purification, inhibition and screening of Ca2+-binding proteins, as well as the preparation of a new affinity chromatography matrix and a new protein biosensor. The invention also relates to the use of the reagent in inhibiting apoptosis and necrosis and in diagnosing a disorder associated with a defect in the function of a Ca2+-binding protein, and in the preparation of a medicament for treating such disorders.
La présente invention concerne un réactif qui se lie spécifiquement aux protéines de liaison de Ca?2+¿, se lie à elles par covalence après photoactivation et les étiquette. Le nouveau réactif permet la caractérisation, la purification, l'inhibition et le criblage des protéines de liaison de Ca?2+¿, ainsi que la préparation d'une nouvelle matrice de chromatographie par affinité et d'un nouveau biocapteur à protéines. L'invention concerne aussi l'utilisation du réactif dans l'inhibition de l'apoptose et de la nécrose, et dans le diagnostic d'un trouble associé avec un défaut de la fonction d'une protéine de liaison de Ca?2+¿, ainsi que dans la préparation d'un médicament destiné à traiter ces troubles.
Israelson Adrian
Shoshan-Barmatz Varda
Ben Gurion University Of The Negev Research And Development Auth
Goudreau Gage Dubuc
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