Non-primate lentiviral vectors and packaging systems

Details Non-primate lentiviral vectors and packaging systems Non-primate lentiviral vectors and packaging systems

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01) A01N 43/04 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2304983

The invention provides non-primate lentiviral vectors, packaging cells and packaging plasmids based, for example, on feline and ungulate retroviruses. In particular, the packaging plasmids are designed for expression in human cells (which are also used as packaging cells). The vectors of the invention transduce human cells, including difficult to target non-dividing cells of the hematopoietic and nervous system, in vitro and in vivo. The vectors are suitable for general gene transfer to these cells and for gene therapy to treat conditions mediated by these non-dividing cells including cancer and HIV infection.

L'invention concerne des vecteurs de lentivirus non originaires de primates, des cellules d'encapsidation et des plasmides d'encapsidation basés, par exemple, sur des rétrovirus de félins et d'ongulés. Ces plasmides d'encapsidation sont, en particulier, conçus pour être exprimés dans des cellules humaines (utilisées également en tant que cellules d'encapsidation). Ces vecteurs opèrent la transduction de cellules humaines, in vitro et in vivo, y compris des cellules du système nerveux et hématopoïétique ne se divisant pas et difficiles à cibler. Ces vecteurs permettent d'effectuer un transfert génique général vers ces cellules et sont appropriés à une thérapie génique afin de traiter des états développés par la médiation de ces cellules ne se divisant pas, y compris le cancer et l'infection par VIH.

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