C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/4196 (2006.01) A61P 19/00 (2006.01) C07D 249/14 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 471/18 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2710230
Bridged bicyclic aryl or heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the receptor protein tyrosine kinase Ax1. Methods of using the compounds in treating diseases or conditions associated with Ax1 activity are also disclosed.
L'invention porte sur des triazoles substitués par aryle ou hétéroaryle bicyclique ponté et sur des compositions pharmaceutiques contenant lesdits composés, qui sont utilisées pour inhiber l'activité de la protéine récepteur de tyrosine kinase Axl. L'invention se rapporte aussi à des procédés d'utilisation desdits composés dans le traitement de maladies ou d'états associés à l'activité d'Axl.
Ding Pingyu
Goff Dane
Holland Sacha
Litvak Joane
Singh Rajinder
Gowling Lafleur Henderson Llp
Rigel Pharmaceuticals Inc.
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