Highly water soluble bis-naphthalimides useful as anticancer...

Details Highly water soluble bis-naphthalimides useful as anticancer... Highly water soluble bis-naphthalimides useful as anticancer...

C - Chemistry, Metallurgy

07

D

C07D 221/14 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2125142

2125142 9312092 PCTABS00022 This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis(methylimino-2,1-ethanediyl)]-bis[5-nitro-1H-benz[de]i_ soquinoline-1,3(2H)-dione], 2-[2-[N-methyl-N-[2-[[2-(5-nitro-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-yl)et_ hyl]amino]ethyl]amino]ethyl]-5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione, 2,2'-[1,2-ethanediylbis(imino-2,1-ethanediyl)]-bis[5-nitro-1H-benz[de]isoquin_ oline-1,3(2H)-dione], pharmaceutical compositions containing them, and methods of using them to treat solid tumor carcinomas in mammals.

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