C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/10 (2006.01) A61P 31/16 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2718923
Monoclonal antibodies directed against the influenza A virus are described, which have the property of being able to bind a plurality of subtypes of the influenza A virus. One preferred embodiment is the antibody designated as Fab28, which displays a neutralizing activity against a plurality of subtypes of the influenza A virus. Anti-idiotype antibodies directed against the monoclonal antibodies of the invention, immunogenic or vaccine compositions comprising the monoclonal antibodies of the invention are also described, as well as therapeutic, prophylactic and diagnostic applications for the monoclonal antibodies of the invention. The monoclonal antibodies of the invention can also be used for testing antibody preparations to be used as vaccines.
L'invention porte sur des anticorps monoclonaux dirigés contre le virus de la grippe A, qui ont la propriété avantageuse et non prédite d'être aptes à se lier à une pluralité de sous-types du virus de la grippe A. Un mode de réalisation préféré porte sur l'anticorps appelé Fab28, qui présente une activité neutralisante contre une pluralité de sous-types du virus de la grippe A. L'invention porte également sur des anticorps anti-idiotypes dirigés contre les anticorps monoclonaux de l'invention, sur des compositions immunogènes ou de vaccin comprenant les anticorps monoclonaux de l'invention, ainsi que sur des applications thérapeutiques, prophylactiques et de diagnostic pour les anticorps monoclonaux de l'invention. Les anticorps monoclonaux de l'invention peuvent également être utilisés pour tester des préparations d'anticorps devant être utilisées en tant que vaccins.
Burioni Roberto
Clementi Massimo
Macrae & Co.
Pomona Ricerca S.r.l.
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