Methods for improvement of lung function using tgf-.beta....

Details Methods for improvement of lung function using tgf-.beta.... Methods for improvement of lung function using tgf-.beta....

A - Human Necessities

61

K

A61K 31/5355 (2006.01) A61K 31/34 (2006.01) A61K 31/381 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01)

Patent

CA 2494367

The invention concerns methods for improvement of lung function by administering non-peptide small molecule inhibitors of TGF-.beta. specifically binding to the type I TGF-.beta. receptor (TGF.beta.-R1). Preferably, the inhibitors are quinazoline derivatives.

L'invention concerne des méthodes pour améliorer la fonction respiratoire par administration de petites molécules non peptidiques agissant en tant qu'inhibiteurs du TGF-.beta., se liant de manière spécifique au récepteur TGF-.beta. de type 1 (TGF.beta.-R1). De préférence, lesdits inhibiteurs sont des dérivés de quinazoline.

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