Pharmaceutical compositions comprising prostanoid-receptor...

A - Human Necessities – 61 – K

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Details

A61K 9/00 (2006.01) A61K 9/06 (2006.01) A61K 31/557 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01)

Patent

CA 2610465

The present invention is related to pharmaceutical compositions comprising prostanoid-receptor agonists, intravaginal dosage forms comprising the same, and methods of making and using the same. The present invention is also related to a controlled release pharmaceutical gel for vaginal administration, the pharmaceutical gel comprising: (a) misoprostol; (b) a cellulose derivative; and (c) a polyol; wherein the gel is a substantially nonaqueous gel, and wherein the gel forms a hydrogel when placed in a vaginal tract.

L'invention concerne des compositions pharmaceutiques comprenant des agonistes des récepteurs prostanoïdes, des formes galéniques intravaginales comprenant celles-ci et des procédés de fabrication et d'utilisation de celles-ci. L'invention concerne également un gel pharmaceutique à libération commandée destiné à une administration vaginale, le gel pharmaceutique comprenant: (a) du misoprostol; (b) un dérivé de cellulose; et (c) un polyol; le gel étant sensiblement non aqueux et formant un hydrogel quand il est placé dans le tractus vaginal.

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