C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2426460
A method of modifying the electrophysiological function of an excitable tissue region of an individual is provided. The method includes the step of implanting cells into the excitable tissue region. Each implanted cell is (a) capable of forming gap junctions with at least one cell of the excitable tissue region; and (b) capable of forming a functional ion channel or transporter, wherein the functional ion channel or transporter is capable of modifying the electrophysiological function of the excitable tissue region.
L'invention concerne une méthode permettant de modifier la fonction électrophysiologique d'une zone de tissus excitables chez un individu. Cette méthode consiste à implanter des cellules dans ladite zone de tissus excitables. Chaque cellule implantée est (a) capable de former des jonctions lacunaires avec au moins une cellule de la zone de tissus excitables, et (b) capable de former un canal ionique fonctionnel ou un transporteur, ledit canal ionique fonctionnel ou transporteur étant capable de modifier la fonction électrophysiologique de la zone de tissus excitables.
Feld Yair
Frank Meira
Gepstein Lior
Marom Shimon
Genegrafts Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Technion Research And Development Foundation Ltd.
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