C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 513/04 (2006.01) A61K 31/4745 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2602083
Thiazolo[4,5-c] ring compounds, (e.g. thiazolopyridine, thiazoloquinoline, 6,7,8,9- tetrahydrothiazoloquinoline, thiazalonaphthyridine, and 6,7,8,9- tetrahydrothiazolonaphthyridine compounds) having an oxime or hydroxylamine substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
La présente invention concerne des composés cycliques Thiazolo[4,5-c], (par exemple la thiazolopyridine, la thiazoloquinoline, la 6,7,8,9-tétrahydrothiazoloquinoline, la thiazolonaphthyridine et les composés 6,7,8,9-tétrahydrothiazolonaphthyridines) possédant un substituant oxime ou hydroxylamine en position 2, des compositions pharmaceutiques renfermant les composés, les produits intermédiaires et les procédés de fabrication et d'utilisation de ces composés comme immunomodulateurs en vue de moduler la biosynthèse de la cytokine chez les animaux et lors du traitement de maladies comprenant des maladies virales et néoplasiques.
Heppner Philip D.
Kshirsagar Tushar A.
Lundquist Gregory D. Jr.
Coley Pharmaceutical Group Inc.
Smart & Biggar
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