C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/22 (2006.01) A61K 31/519 (2006.01) A61K 31/5383 (2006.01) A61P 29/00 (2006.01) C07D 495/14 (2006.01) C07D 498/22 (2006.01)
Patent
CA 2623026
In its many embodiments, the present invention provides tetracyclic compounds of formula (I) or formula (II) (wherein the various moieties are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
L'invention concerne, dans de nombreux modes de réalisation, des composés tétracycliques de formule (I) ou (II) (dans lesquelles les divers fragments ont la signification indiquée dans la description) utiles en tant qu'antagonistes du récepteur glutamate métabotropique (mGluR), en particulier en tant qu'antagonistes du récepteur glutamate métabotropique 1. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, et des méthodes de traitement faisant intervenir lesdits composés et compositions pour traiter des maladies associées au récepteur glutamate métabotropique (par exemple, le mGluR1) de type douleurs, migraine, anxiété, incontinence urinaire et maladies neurodégénératives comme la maladie d'Alzheimer.
Burnett Duane A.
Wu Wen-Lian
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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