Detection of a biomarker of aberrant cells of...

Details Detection of a biomarker of aberrant cells of... Detection of a biomarker of aberrant cells of...

G - Physics

01

N

G01N 33/53 (2006.01) C12Q 1/04 (2006.01) G01N 33/563 (2006.01) G01N 33/68 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2646040

The invention relates to an assay for detecting aberrant cells of neuroectodermal origin in a body fluid of an individual, and comprises testing for expression of GLAST1b as a biomarker of the cells. Intact GLAST1b and/or fragments thereof may be detected in the fluid. Alternatively, another analyte indicative of the expression of GLAST1b by the cells may be detected. The assay is particularly suitable for detecting expression of aberrant neuronal populations such as resulting from brain hypoxia. The fluid can be cerebrospinal fluid (CSF).

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