C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 311/74 (2006.01) A61K 31/325 (2006.01) A61K 31/352 (2006.01) A61K 31/40 (2006.01) A61K 31/4035 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/415 (2006.01) A61K 31/4192 (2006.01) A61K 31/4196 (2006.01) A61K 31/42 (2006.01) A61K 31/423 (2006.01) A61K 31/428 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07C 39/367 (2006.01) C07C 233/25 (2006.01) C07C 233/26 (2006.01) C07C 233/60 (2006.01) C07C 271/42 (2006.01) C07C 307/06 (2006.01) C07C 311/04 (2006.01) C07C 31
Patent
CA 2468413
Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasma level of free fatty acids, glycerol, LDL-cholesterol, HDL-cholesterol, insulin and/or glucose; and or modulate intracellular triacylglycerol and cholesterol stores, intracellular level of fatty acids, fatty acid esters such as diacylglycerols, phosphatidic acids, long chain acyl-CoA's as well as citrate or malonyl-CoA; and or increase insulin sensitivity ; and or modulate insulin secretion from pancreatic beta cells. More particularly said disorders are selected from the group consisting of insulin resistance, diabetes type 1, diabetes type 2, metabolic syndrome X, impaired glucose tolerance, hyperclycemia, dislipidemia, obesity, abnormalities of lipoprotein metabolism and any combinations. thereof.
Cette invention concerne l'utilisation de composés capables de ralentir l'activité de la lipase hormono-sensible, des compositions pharmaceutiques renfermant ces composés, des méthodes de traitement faisant intervenir ces composés et ces compositions, et des nouveaux composés. Les composés selon l'invention sont des inhibiteurs de la lipase hormono-sensible. Ils peuvent être utiles pour le traitement et/ou la prévention de troubles médicaux pour lesquels un ralentissement de l'activité de la lipase hormono-sesnsible est souhaitable.
Cornelis de Jong Johannes
Ebdrup Soren
Hansen Holger Claus
Jacobsen Poul
Vedso Per
Mccarthy Tetrault Llp
Novo Nordisk A/s
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