A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4035 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2505003
Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent, and/or the transplantation of blood or cells. Particular second active agent is capable of suppressing the overproduction of hematopoietic stem cells or ameliorating one or more of the symptoms of MPD. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.
L'invention concerne des méthodes de traitement, de prévention et/ou de gestion d'une maladie myéloproliférative (MPD). Des méthodes spécifiques consistent à administrer un agent inhibiteur sélectif de la cytokine, ou un sel, solvate, hydrate, stéréoisomère, clathrate ou promédicament pharmaceutiquement acceptable de celui-ci, seul ou en association avec un second agent actif, et/ou à effectuer une transplantation sanguine ou cellulaire. Un second agent actif particulier peut lutter contre la surproduction de cellules souches hématopoïétiques ou améliorer un ou plusieurs des symptômes de la MPD. L'invention concerne également des compositions pharmaceutiques, des formes posologiques unitaires et des trousses pouvant être utilisées dans les méthodes selon l'invention.
Celgene Corporation
Osler Hoskin & Harcourt Llp
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