Human gtp-binding proteins

Details Human gtp-binding proteins Human gtp-binding proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/46 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2274735

The present invention provides three novel GTP-binding proteins (designated individually as BND-1, BND-2, and BND-3, and collectively as BND) and polynucleotides which identify and encode BND. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding BND and a method for producing BND. The invention also provides for use of BND and agonists, antibodies, or antagonists specifically binding BND, in the prevention and treatment of diseases associated with expression of BND. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding BND for the treatment of diseases associated with the expression of BND. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding BND.

La présente invention concerne trois nouvelles protéines se liant à la guanosine triphosphate (dénommées individuellement BND-1, BND-2, et BND-3, et collectivement BND), et des polynucléotides identifiant et codant BND. L'invention concerne également des vecteurs d'expression et des cellules hôtes mis au point par génie génétique et comprenant les séquences d'acide nucléique codant BND et une méthode de production de BND. L'invention concerne, en outre, l'utilisation de BND ainsi que d'agonistes, d'anticorps ou d'antagonistes se liant spécifiquement à BND, pour la prévention et le traitement d'affections associées à l'expression de BND. L'invention concerne encore l'utilisation de molécules antisens de polynucléotides codant BND pour le traitement d'affections associées à l'expression de BND. L'invention concerne enfin l'utilisation de méthodes diagnostiques faisant appel au polynucléotide, à des fragments ou au complément du polynucléotide, ainsi qu'à des anticorps se liant spécifiquement à BND.

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