C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4545 (2006.01) A61P 31/12 (2006.01)
Patent
CA 2671473
The present invention relates to 4-{(1R,3R)-1-(3,5-difluorophenyl)-3-[4-(3-ethyl-5- isopropyl-4H- 1,2,4-triazol-4-yl)piperidin- 1 -yl]butyl} - 1 -(methylsulfonyl)piperidine formula (I) : or a pharmaceutically acceptable salt thereof, as well as to processes for preparing such a compound, to pharmaceutical compositions comprising such a compound and to the use of such a compound in the treatment of CCR5 mediated disease states.
La présente invention concerne une 4-{(1R,3R)-1-(3,5-difluorophényl)-3-[4-(3-éthyl-5-isopropyl-4H-1,2,4-triazol-4-yl)pipéridin-1-yl]butyl}-1-(méthylsulfonyl)pipéridine (I) : ou l'un de ses sels acceptables d'un point de vue pharmaceutique, ainsi que des procédés de préparation d'un tel composé, des compositions pharmaceutiques comprenant un tel composé et l'utilisation d'un tel composé dans le traitement d'états pathologiques médiés par le CCR5.
Brown Dearg Sutherland
Faull Alan Wellington
Swallow Steven
Astrazeneca Ab
Fetherstonhaugh & Co.
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